ISIS Neutron and Muon Source Data Journal

Molecular interactions of Paracetamol in solution

Abstract: Active Pharmaceutical Ingredients (APIs) are frequently delivered to the patient in the solid state as part of an approved dosage form (e.g. tablets, capsules, etc.) Drug compounds tend to crystallise into different crystal forms depending on their environment, one of these influences can be the type of solvent used. We are investigating the factors that lead to the crystallisation of different forms with special interest in comparing molecular interactions in the neet amorphous state (melt) with that in solution. Paracetamol exists in at least three polymorphs (forms I, II and III) with only form III formed from the melt. In a successful proposal we are scheduled to measure paracetamol in the neat melt. We now propose to measure total neutron scattering on SANDALS for paracetamol in DMSO solution to investigate the molecular interactions leading to the crystallisation of form I

Principal Investigator: Dr Katharina Edkins
Experimenter: Dr Robert Edkins
Experimenter: Miss Yitian Xiao
Local Contact: Dr Sabrina Gaertner
Experimenter: Dr Silvia Imberti
Experimenter: Mr Robert Boyd
Local Contact: Dr Oliver Alderman

DOI: 10.5286/ISIS.E.RB1910427

ISIS Experiment Number: RB1910427

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Katharina Edkins et al; (2019): Molecular interactions of Paracetamol in solution, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1910427

Data is released under the CC-BY-4.0 license.