ISIS Neutron and Muon Source Data Journal

Investigating the Influence of Polymer Properties on Cyclic Peptide-Polymer Conjugate Nanotube Length

Abstract: Cyclic peptides with alternating side chain stereochemistry are capable of self-assembling into long nanotubes (CPNTs). The conjugation of polymers to these peptides renders the resulting nanotubes water soluble, whilst providing functionality. CPNTs have promising applications in drug delivery where nanotube length dictates their bioavailability. However, we have limited understanding of how the chemistry of the polymers influences nanotube length. Here we propose to investigate how changing polymer properties such as molecular weight, hydrophobicity and aromaticity modulate the length of CPNTs. Spin-echo small angle neutron scattering is the ideal technique to investigate this question, able to resolve the real space distance distribution of CPNTs over large length scales. This information will facilitate the design of CPNTs of controlled length for drug delivery applications.

Principal Investigator: Professor Sebastien Perrier
Experimenter: Dr Qiao Song
Experimenter: Miss Maria Kariuki
Experimenter: Dr Robert Dalgliesh
Experimenter: Dr Stephen Hall

DOI: 10.5286/ISIS.E.RB1920529

ISIS Experiment Number: RB1920529

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Sebastien Perrier et al; (2019): Investigating the Influence of Polymer Properties on Cyclic Peptide-Polymer Conjugate Nanotube Length, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1920529

Data is released under the CC-BY-4.0 license.