ISIS Neutron and Muon Source Data Journal

Transmigration of alternating amphiphilic polymers through lipid membranes

Abstract: Polymers with a very balanced hydrophilicity can translocate through biological membranes without doing damage. This simulates natural metabolism, and, therefore, allow for targeting certain drugs or agents into the cell interior [1]. We have synthesized such balanced, alternating hydrophobic/hydrophilic polymers and proved their translocation through lipid bilayer using Pulsed Field Gradient NMR technique. However, with this technique we can’t exclude that some part of the polymers is attracted by lipid bilayer and therefore excluded from transmigration process. Now we want to test if the attraction takes place in our system using small angle neutron scattering.[1] M. Werner, J.-U. Sommer, V. A. Baulin, Soft Matter 2012, 8, 11714

Principal Investigator: Mr Henrich Frielinghaus
Experimenter: Mrs Ekaterina Kostyurina
Experimenter: Dr Allgaier
Local Contact: Dr Najet Mahmoudi

DOI: 10.5286/ISIS.E.RB1920119

ISIS Experiment Number: RB1920119

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Mr Henrich Frielinghaus et al; (2019): Transmigration of alternating amphiphilic polymers through lipid membranes, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1920119

Data is released under the CC-BY-4.0 license.