ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Packing of DNA in glioma nuclei
Abstract: To answer the question how DNA is packed inside the interphase nucleus at the micron scale, we propose SESANS experiment using contrast variation technique from human glioma nuclei. The previous SESANS measurements from chicken erythrocite and HeLa nuclei in D2O have shown exponential SESANS correlation function of the nucleus. The exponential decay of the SESANS function indicates that nucleas has a logarithmic correlation function on the micron scale [Iashina (2017)]. Logarithmic correlation function correspond to hierarchically branched structure like a tree. Such structure provides high accessibility of enzymes to specific gene site.
Principal Investigator: Dr Wim Bouwman
Experimenter: Professor Sergey Grigoriev
Local Contact: Dr Robert Dalgliesh
Experimenter: Ms Ekaterina Iashina
Experimenter: Mr Christiaan Duif
Experimenter: Professor Sergey Grigoryev
DOI: 10.5286/ISIS.E.RB1920181
ISIS Experiment Number: RB1920181
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB1920181-1 | LARMOR | 03 October 2022 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Wim Bouwman et al; (2019): Packing of DNA in glioma nuclei, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1920181
Data is released under the CC-BY-4.0 license.
