ISIS Neutron and Muon Source Data Journal

Conformational changes of human growth hormone driven by the interaction with non-ionic surfactants

Abstract: The tale of protein-surfactant interactions has been the goal of many scientific investigations in the last few decades. The interaction between proteins and amphiphiles in solution are of wide interest due to the ubiquity of these compounds in pharmaceutical formulations and health care products. However, detailed structural models of protein-surfactant complexes are still rather scarce and general consensus is yet missing. The aim of this experiment is to elucidate the mechanism of interaction of human growth hormone with a set of non-ionic surfactants (polysorbate 20, octaethylene glycol monododecyl ether, and dodecylmaltoside) by means of contrast-variation SANS. The main goal will be to identify the characteristics of the surfactant-protein complexes, the effect of the surfactant in the protein conformation and the interactions occurring in each system.

Principal Investigator: Dr Adrian Sanchez-Fernandez
Experimenter: Dr Judith Houston
Local Contact: Dr Sarah Rogers
Experimenter: Dr Marie Wahlgren
Experimenter: Dr Helen Sjogren
Experimenter: Mr Johan Larsson

DOI: 10.5286/ISIS.E.RB1910529

ISIS Experiment Number: RB1910529

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Adrian Sanchez-Fernandez et al; (2019): Conformational changes of human growth hormone driven by the interaction with non-ionic surfactants, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1910529

Data is released under the CC-BY-4.0 license.