ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Aggregation behaviour of PEGylated ibuprofen
Abstract: In the present study the acidic, anti-inflammatory drug, ibuprofen has been PEGylated using an polyoxyethylene chain of 750 molecular weight. The consequence of this PEGylation is the preparation of an amphiphilic, unionized version of the drug. The aim of the study is to determine the aggregation behavior of the molecule in aqueous solution using small angle neutron scattering in combination with contrast variation. The ultimate goal of the project is the preparation of a version of ibuprofen that can be administered safely in the form of a self-assembled micelle in which ibuprofen acts as its own delivery vehicle.
Principal Investigator: Professor Jayne Lawrence
Experimenter: Dr Dave Barlow
Local Contact: Dr Najet Mahmoudi
Experimenter: Dr Manikandan Kadirvel
Experimenter: Dr Mark Jackman
Experimenter: Mr Weimin Li
Experimenter: Dr Alice Spadea
Experimenter: Dr Yu Lu
Experimenter: Miss Yixuan Yan
DOI: 10.5286/ISIS.E.RB1910532
ISIS Experiment Number: RB1910532
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB1910532-1 | SANS2D | 15 June 2022 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
Select the data format above to find
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Professor Jayne Lawrence et al; (2019): Aggregation behaviour of PEGylated ibuprofen, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1910532
Data is released under the CC-BY-4.0 license.
