ISIS Neutron and Muon Source Data Journal

UNDERSTANDING NORMAL-TO-CANCER TRANSITION IN HUMAN CELLS WITH THE USE OF NEUTRONS

Abstract: Normal-to-malignant transformation in human cells, still an ill-understood process, is intimately related to their biomechanical properties, which are strongly dependent on the intracellular water structural and dynamical profiles. Indeed, these are known to play a fundamental role in normal cellular activity, namely through maintenance of the three-dimensional architecture and functional conformation of biopolymers. Building on the success of previous experiments on the impact of an anticancer drug on the cytomatrix of breast cancer cells [1,2], the present study aims to apply QENS for probing changes in intracellular water dynamics between healthy and cancer human cells. This is an innovative approach for unveiling particular features of malignant cells and attain specific spectroscopic signatures of cancer, aiming at a better understanding of the normal-to-cancer transition.

Principal Investigator: Dr Maria Paula Marques
Experimenter: Dr Ana Batista de Carvalho
Local Contact: Dr Victoria Garcia Sakai
Experimenter: Dr Joana Marques
Experimenter: Miss Adriana Mamede
Experimenter: Dr Luis Alberto Batista de Carvalho

DOI: 10.5286/ISIS.E.RB1910015

ISIS Experiment Number: RB1910015

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Maria Paula Marques et al; (2019): UNDERSTANDING NORMAL-TO-CANCER TRANSITION IN HUMAN CELLS WITH THE USE OF NEUTRONS, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1910015