ISIS Neutron and Muon Source Data Journal

Structural evidence of lipopolysaccharides functioning as receptors in antimicrobial action for antimicrobial peptides

Abstract: The global increase of bacterial resistance to antibiotics has led to increasing interest in research focusing on the development and characterization of new antimicrobial agents. One class of promising antimicrobials found in nature are Antimicrobial Peptides (AMP’s). We have designed different amphiphilic AMPs by balancing their antimicrobial potency against their cytotoxicity to mammalian host cells. In this work, we propose to use neutron reflection to characterise the model lipid bilayers mimicking the outer membrane of Gram-negative E. coli, followed by the characterisation of binding of 3 representative AMPs. In this exploratory study we wish to identify the structural evidence to support the belief of recruitment of AMPs by lipopolysaccharides, a crucial step in effective bactericidal action.

Principal Investigator: Professor Jian Lu
Experimenter: Miss Daniela Ciumac
Local Contact: Dr Luke Clifton
Experimenter: Mr Haoning Gong
Experimenter: Dr Mingrui Liao
Experimenter: Dr Xuzhi Hu

DOI: 10.5286/ISIS.E.RB1910068

ISIS Experiment Number: RB1910068

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jian Lu et al; (2019): Structural evidence of lipopolysaccharides functioning as receptors in antimicrobial action for antimicrobial peptides, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1910068

Data is released under the CC-BY-4.0 license.