ISIS Neutron and Muon Source Data Journal

Interaction of trehalose and a model peptide

Abstract: We propose to perform a NDIS experiments at the SANDALS diffractometer at T = 300 K on X samples of N-Methylacetamide, NMA, and trehalose at low water content, in the glassy state. We have already measured on SANDALS the structure of the hydration shell of NMA in pure aqueous solution and with addition of trehalose. These data show that the hydration shell does not sensibly change when trehalose is added to the solution and that trehalose does not directly interact with the other solute and seems to segregate first hydration shell water molecules in the vicinity of NMA. This result may be of great relevance for understanding the biological mechanism adopted by trehalose as a protectant against drought, supporting the so-called "segregation" scenario against the "substitution" one. The results found in liquid solution need to be confirmed in the glassy state obtained at low water conten

Principal Investigator: Professor Maria Antonietta Ricci
Local Contact: Dr Silvia Imberti
Experimenter: Professor Fabio Bruni
Experimenter: Dr Michael Di Gioacchino

DOI: 10.5286/ISIS.E.RB1910141

ISIS Experiment Number: RB1910141

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Maria Antonietta Ricci et al; (2019): Interaction of trehalose and a model peptide, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1910141

Data is released under the CC-BY-4.0 license.