ISIS Neutron and Muon Source Data Journal

Interaction of lamellar and non-lamellar lipid mesophases with inorganic nanoparticles

Abstract: The behavior of inorganic nanoparticles (NPs) with biological interfaces is a key research topic, to boost Nanomedicine development. In this respect, 2D lipid assemblies are reliable biomimetic models of cell membranes, allowing to investigate nano-bio interactions in simplified conditions. We propose a Neutron Reflectometry (NR) investigation on lipid films of different architectures, i.e., lamellar structure of glyecrylmonooleate mixed with lecithin (GMO-lec) compared to cubic structure of GMO, in their interaction with different inorganic nanoparticles. Lipid films will be challenged with NPs of different core (gold or magnetite), shape (sphere or rod) and diverse surface functionalization (hydrophilic, hydrophobic). The experimental results will contribute to the understanding of the effects of the physicochemical features of NPs on target lipid membranes of different structure.

Principal Investigator: Dr Costanza Montis
Experimenter: Mr Andrea Ridolfi
Experimenter: Professor Tommy Nylander
Local Contact: Dr Nina-Juliane Steinke
Experimenter: Professor Debora Berti
Experimenter: Dr Marco Mendozza
Experimenter: Dr Lucrezia Caselli
Experimenter: Mr Emil Gustafsson

DOI: 10.5286/ISIS.E.RB1910376

ISIS Experiment Number: RB1910376

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Costanza Montis et al; (2019): Interaction of lamellar and non-lamellar lipid mesophases with inorganic nanoparticles, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1910376

Data is released under the CC-BY-4.0 license.