ISIS Neutron and Muon Source Data Journal

Tuning the Molecular Exchange Kinetics of Self-Assembled Antimicrobial Peptide- Polymer Conjugates

Abstract: Self-assembling antimicrobial peptides (SAAMPs) are promising candidates for antibiotic substitutes. The self-assembled structure provides proteolytic stability to the individual antimicrobial peptides. Since those need to target the bacterial membrane as unimers, the molecular exchange kinetics of the SAAMPs are of fundamental interest. In the proposed experiment we would like to investigate the exchange mechanism(s) of previously reported SAAMP-polymer conjugates. This will be achieved in a kinetic zero-average contras tscheme using time-resolved small-angle neutron scattering. By varying pH (assembly stability), temperature (exchange time) and sample concentration (collision-induced mechanisms), we will systematically study the molecular exchange pathways of SAAMPs, enabling the future tailoring in drug applications.

Principal Investigator: Professor Reidar Lund
Experimenter: Mr Nico Koenig
Local Contact: Dr Najet Mahmoudi
Experimenter: Mr Luis Willner
Experimenter: Dr Lutz Willner

DOI: 10.5286/ISIS.E.RB1910106

ISIS Experiment Number: RB1910106

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Reidar Lund et al; (2019): Tuning the Molecular Exchange Kinetics of Self-Assembled Antimicrobial Peptide- Polymer Conjugates, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1910106

Data is released under the CC-BY-4.0 license.