ISIS Neutron and Muon Source Data Journal

Regulation of Myc-Max DNA binding in cancer. Part 1: The Max homodimer

Abstract: The Myc-Max heterodimer assembly is a central hub in cellular growth control, by regulating a wealth of biological functions. Increased Myc levels in the cell are caused by mutations disrupting ubiquitination and/or translocation, and result in an increment of Myc-Max heterodimer formation over the Max-Max homodimer. Uncontrolled Myc expression disturbs the balance of cell growth regulation, which turns the Myc-Max heterodimer into an oncoprotein and a key contributor to the development of many human cancers. To bind the DNA, the c-terminal region of Myc must form a heterodimer with the Max, but the Max is able to form a homodimer. Since X-Ray crystallography and NMR have failed to describe entire Max-Max or Myc-Max protein assemblies. Therefore, we intend to use SANS to investigate the structured envelope of DNA-bound complexes of Max-Max and Max-Myc.

Principal Investigator: Mrs Maria Sunnerhagen
Experimenter: Miss Zuzanna Pietras
Local Contact: Dr Najet Mahmoudi
Experimenter: Ms Anne Martel
Experimenter: Miss Francesca Caporaletti

DOI: 10.5286/ISIS.E.RB1910238

ISIS Experiment Number: RB1910238

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Mrs Maria Sunnerhagen et al; (2019): Regulation of Myc-Max DNA binding in cancer. Part 1: The Max homodimer, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1910238

Data is released under the CC-BY-4.0 license.