ISIS Neutron and Muon Source Data Journal

Encapsulation of Non-Steroidal Anti-Inflammatory Drugs Using Novel Pluronic Graft Copolymers

Abstract: The research topic is encapsulation of a hydrophobic drug, flurbiprofen, using novel amphiphilic graft copolymers (AGCs). The AGCs of interest are shown in Figure 1: Preliminary Small-angle neutron scattering (SANS) has been used to characterize the conformation of the P123 and P103 Pluronic graft copolymers in selective solvents such as ethanol and water in the presence of flurbiprofen. The results indicate that, when the drug is added into the solution of grafted copolymers, an increase in the inner (Rin/Å) and outer radius (Rout/Å) is observed. Also results by diffusion NMR show a distinct decrease in the attenuation of drug (decrease in diffusion coefficient), which indicate that the drug is interacting with micelles. The proposal is being of significance in designing potential drug carriers that are not concentration sensitive.

Experimenter: Professor Terence Cosgrove
Experimenter: Dr Covadonga Correas López
Experimenter: Dr Virginia Gomez Jimenez
Experimenter: Dr Shirin Alexander
Local Contact: Dr Sarah Rogers

DOI: 10.5286/ISIS.E.RB1520016

ISIS Experiment Number: RB1520016

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Terence Cosgrove et al; (2015): Encapsulation of Non-Steroidal Anti-Inflammatory Drugs Using Novel Pluronic Graft Copolymers, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1520016

Data is released under the CC-BY-4.0 license.