ISIS Neutron and Muon Source Data Journal

Effect of steroid structure on solubilisation in a series of C12 surfactant micelles

Abstract: The current project aims to probe (at the nanometer length scale) the relationship between the structure of a surfactant molecule, the micelles it forms in solution, and the drug molecules that its micelles can solubilise. Once obtained this understanding should allow the ration design of novel surfactant molecules to form micelles in which the drug loading is optimized. In the present study a series of structurally related steroidal drug molecules, namely 4-cholesten-3-one and adrenosterone will be solubilised in micelles formed from C12 surfactants with differing head groups. The results of the study will be complemented by molecular dynamic simulations of the drug in the surfactant micelles using the aggregation number obtained from SANS. The results of the study are essential to aiding the rational design and selection of surfactant micelles to optimise drug solubilisation.

Principal Investigator: Professor Jayne Lawrence
Experimenter: Ms Orathai Loruthai
Experimenter: Dr Shaun McCaffrey
Local Contact: Dr Richard Heenan
Experimenter: Dr Ann Terry
Experimenter: Dr Dave Barlow
Experimenter: Dr Hisham Al-Obaidi
Experimenter: Miss yanan shao

DOI: 10.5286/ISIS.E.RB1520330

ISIS Experiment Number: RB1520330

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jayne Lawrence et al; (2015): Effect of steroid structure on solubilisation in a series of C12 surfactant micelles, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1520330

Data is released under the CC-BY-4.0 license.