ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Structure of the myoglobin-trehalose-water system
Abstract: In this proposal we will study the structure of the myoglobin-trehalose-water system. It is well known that trehalose has an excellent cryo- and bioprotective role for biomaterials, such as proteins. However, the exact mechanism of it is still widely debated, mainly because structural insights of the protein-trehalose-water system are lacking. Two main models have been proposed; the preferential hydration (or water entrapment) model, where water prefers to hydrogen bond to the protein surface, and the water replacement model, where the trehalose molecules display the water molecules at the protein surface. Our recent TGA measurements support the latter model, and we will now establish the correct structural model as well as to gain structural information of help to understand the dynamic results from a complementary IRIS experiment on the same system.
Principal Investigator: Professor Jan Swenson
Experimenter: Mr Christoffer Olsson
Local Contact: Dr Tristan Youngs
Experimenter: Dr Helen Jansson
DOI: 10.5286/ISIS.E.RB1520094
ISIS Experiment Number: RB1520094
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.67773750 | NIMROD | 07 November 2018 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
Select the data format above to find
out more about it.
Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Professor Jan Swenson et al; (2015): Structure of the myoglobin-trehalose-water system, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1520094
Data is released under the CC-BY-4.0 license.
