ISIS Neutron and Muon Source Data Journal

A Total Scattering Investigation of the Intermolecular Interactions in Low Aqueous Solubility Amorphous Pharmaceuticals.

Abstract: Low bioavailability is a major problem in drug formulation development; low aqueous solubility of an active pharmaceutical ingredient can stall development of a potentially useful drug through its limited bioavailability, and hence limited efficacy, after administration. The growing interest in the use of amorphisation in order to enhance solubility of active pharmaceutical ingredients has led to the investigation of methods to improve the stability of the amorphous state. The proposed experiment aims to use neutron total scattering information to investigate the intermolecular interactions formed in the amorphous state below and above the Tg and how these affect the molecular mobility. This will assist in understanding the storage conditions required to maintain shelf life stability, and understanding the metastable state prior to crystallisation.

Principal Investigator: Dr Sam Callear [Deactivated]

DOI: 10.5286/ISIS.E.RB1510018

ISIS Experiment Number: RB1510018

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Sam Callear [Deactivated]; (2015): A Total Scattering Investigation of the Intermolecular Interactions in Low Aqueous Solubility Amorphous Pharmaceuticals., STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1510018

Data is released under the CC-BY-4.0 license.