ISIS Neutron and Muon Source Data Journal

Investigations of amorphous pharmaceutical materials produced from different routes

Abstract: Pharmaceuticals are usually formulated in the crystalline state for obvious reasons of stability. They may also exist in a disordered and less cohesive state i.e. amorphous offering an interesting alternative route since it offers greater solubility. The amorphous state can be produced by many different techniques : quench from the melt, grinding or freeze-drying. Although the characterization of amorphous pharmaceuticals has received considerable attention, little is actually known about the amorphisation process itself and the precise physical stresses altering the physical state undertaken during the transformation processes (temperature, pressure, shearing, dehydration). The aim of this research proposal is thus to obtain a clear physical understanding of the transformation mechanisms induced by these different methods by using combined neutron scattering and MD simulations.

Principal Investigator: Dr Frederic Affouard
Local Contact: Dr Victoria Garcia Sakai
Experimenter: Dr Monica Jimenez-Ruiz
Experimenter: Mr Frédéric NGONO MEBENGA
Experimenter: Dr Gabriel Cuello
Experimenter: Dr Jean-François WILLART

DOI: 10.5286/ISIS.E.RB1520334

ISIS Experiment Number: RB1520334

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Frederic Affouard et al; (2015): Investigations of amorphous pharmaceutical materials produced from different routes, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1520334

Data is released under the CC-BY-4.0 license.