ISIS Neutron and Muon Source Data Journal

Understanding the microstructure of polymer blends used as control release coatings.

Abstract: Solid oral dosage forms consist of polymer layer encapsulated drug-bound particles with a desired drug release profile e.g. pulsatile, controlled, delayed and targeted, depending upon the polymer(s) employed. Therefore, an intimate understanding of the solution phase polymer-polymer interactions during the deposition of the controlled release film formation is critical to ensure consistent performance (e.g. drug release & stability) of the product. The most common film former is ethylcellulose (EC), whereas the permeability enhancer is often hydroxypropyl methylcellulose (HPMC). Solvency has a pronounced effect on the miscibility of the two polymers within the dispersion, and the resultant film properties. Here, we wish to quantify the solution conformations by SANS of two such polymers in single and binary solutions as a function of solvent composition and temperature.

Principal Investigator: Professor Peter Griffiths
Experimenter: Miss Leesa Patel
Experimenter: Dr Gerard Byrne
Experimenter: Dr Beatrice Cattoz
Local Contact: Dr Sarah Rogers
Experimenter: Dr Omar Mansour

DOI: 10.5286/ISIS.E.RB1520364

ISIS Experiment Number: RB1520364

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Peter Griffiths et al; (2015): Understanding the microstructure of polymer blends used as control release coatings., STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1520364

Data is released under the CC-BY-4.0 license.