ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Interaction of the nucleic acid, DNA, with a model biomembrane at the oil-water interface
Abstract: The information gained in the study will be invaluable in aiding our understanding of the structure and transport properties of the cell membrane as well as helping in the development of vehicles to improve the delivery of nucleic acids (i.e. gene). In this experiment we would like to investigate the intermolecular interactions that occur between nucleic acids (i.e. siRNA/DNA) with mixed phospholipid/cholesterol monolayers at the oil-water interface in the presence of the divalent cation, Ca++, using neutron reflectometry in combination with contrast variation. The conformational order of the film as function of DNA/siRNA concentration will be studied and compared with comparable films at the (simpler) air-water interface.
Principal Investigator: Dr Ali Zarbakhsh
Experimenter: Dr John Webster
Experimenter: Professor Jayne Lawrence
DOI: 10.5286/ISIS.E.RB1510274
ISIS Experiment Number: RB1510274
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.63525140 | INTER | 16 September 2018 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Ali Zarbakhsh et al; (2015): Interaction of the nucleic acid, DNA, with a model biomembrane at the oil-water interface, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1510274
Data is released under the CC-BY-4.0 license.
