ISIS Neutron and Muon Source Data Journal

Structural studies on drugs and lipids in amphiphilic solutions

Abstract: How drugs cross the formidable blood brain barrier in order to function is not well understood, specifically with respect to the interplay between hydrophobic and hydrophilic interactions in solution. BBB-crossing drugs must be hydrophilic enough to be delivered to the brain through the blood stream, yet hydrophobic enough to cross into the central nervous systems. Here we propose to investigate the atomic structure of a drug which can cross the BBB with lipids in amphiphilic solutions which mimic the environment presented by the the central nervous system. This will provide atomic scale insights into the mechanisms by which drugs molecules can pass into the brain in order to function.

Principal Investigator: Dr Sylvia McLain
Local Contact: Dr Sam Callear [Deactivated]
Experimenter: Dr Ric Gillams
Experimenter: Mr Christopher Sowden
Experimenter: Mr Andrew Johnston
Experimenter: Dr Natasha Rhys
Experimenter: Dr Richard Gillams

DOI: 10.5286/ISIS.E.RB1520209

ISIS Experiment Number: RB1520209

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Sylvia McLain et al; (2015): Structural studies on drugs and lipids in amphiphilic solutions, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1520209

Data is released under the CC-BY-4.0 license.