ISIS Neutron and Muon Source Data Journal

This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.


Interactions between lipoprotein particles from human serum and model blood vessel surfaces - Implications on atherosclerosis development.

Abstract: In westernised societies, atherosclerosis and its clinical consequences such as heart disease and stroke constitute the leading cause of death. Thus, the prevention or deceleration of atherogenesis is one of the most significant medical objectives since this is a matter of avoiding myocardial and cerebral infarction. Taken together, current knowledge recognises a whole range of indicators associated with atherosclerosis, including the relative concentration of various lipoprotein particles. Here, we propose to study the structure of lipoprotein particles at the surface of various components of the vessel wall. For this we will start with the well characterised heparan sulfate - LDL/HLD system to unravel the fate of the lipoprotein particle components in the heparan sulfate coated silica surfaces by means of neutron reflection. We start with lipoprotein particles from human blood.

Principal Investigator: Professor Marité Cárdenas Gómez
Experimenter: Dr Kathryn Browning
Local Contact: Dr Maxmilian Skoda
Experimenter: Dr Selma Maric
Experimenter: Miss Sofie Hedegaard
Experimenter: Dr Tania Lind
Experimenter: Professor Martin Malmsten

DOI: 10.5286/ISIS.E.RB1520017

ISIS Experiment Number: RB1520017

Part DOI Instrument Public release date Download Link
10.5286/ISIS.E.67769485 INTER 18 December 2018 Download

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Marité Cárdenas Gómez et al; (2015): Interactions between lipoprotein particles from human serum and model blood vessel surfaces - Implications on atherosclerosis development., STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1520017

Data is released under the CC-BY-4.0 license.



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