ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Effect of the "host-guest" interactions on the low frequency vibrational dynamics of Gen/beta-CyD and Gen/SBE-beta-CyD inclusion complexes
Abstract: Complexation is of interest in pharmaceutical field, since it increases solubility and bioavailabilityof drugs. We want to perform a inelastic neutron scattering (INS) study, vs. T, of the vibrational dynamics of the inclusion complexes of beta-Cyclodextrin (beta-CyD) and its derivative sulfobutylether-beta-Cyclodextrin (SBE-beta-CyD) with Genistein, an antioxidant phytoestrogen, compared to single components and physical mixtures. The aim is to examine if and how the dynamics of the complexes in the ps-ns timescale is affected by the host-guest interactions, and to probe if there exists a relationship of this dynamics with the stability. The comparative analysis of will also allow to test the access offered by these two macrocycles to Genistein. The results are relevant to tailor the release of drugs with specific properties.
Principal Investigator: Professor Valentina Venuti
Experimenter: Miss Cettina Bottari
Experimenter: Professor Vincenza Crupi
Experimenter: Professor Ines Mancini
Experimenter: Professor Domenico Majolino
Experimenter: Dr Alessandro Paciaroni
Experimenter: Professor Graziano Guella
Local Contact: Dr Ian Silverwood
Experimenter: Dr Barbara Rossi
Experimenter: Dr Rosanna Stancanelli
DOI: 10.5286/ISIS.E.RB1520179
ISIS Experiment Number: RB1520179
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.67771490 | TOSCA | 01 December 2018 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
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For Example:
Professor Valentina Venuti et al; (2015): Effect of the "host-guest" interactions on the low frequency vibrational dynamics of Gen/beta-CyD and Gen/SBE-beta-CyD inclusion complexes, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1520179
Data is released under the CC-BY-4.0 license.
