ISIS Neutron and Muon Source Data Journal

Using negative muons as a non-destructive probe of biomaterials

Abstract: Expanding the provision of tools for trace element analysis of biomaterials is very attractive, especially where the tools can be used non-destructively and permit analysis throughout an intact sample volume. Some elements are notoriously difficult to analyse in biological material such as soft tissue, due to a lack of specificity (e.g. histological staining to distinguish copper and zinc), sensitivity (e.g. to trace metals such as manganese), or where elements are lost during tissue preparation and sectioning. In recent years, synchrotron micro- and nano-focussed X-ray fluorescence (XRF) mapping has been optimised as a sensitive, element-specific, non-destructive alternative to laser-ablation ICP-MS mapping, and this has been applied in many contexts including the dysregulation of transition metal metabolism in neurodegenerative disorders such as Alzheimer?s and Parkinson?s disease.

Principal Investigator: Dr Adrian Hillier
Experimenter: Dr Joanna Collingwood
Experimenter: Professor Don Paul
Experimenter: Dr Katsuhiko Ishida
Experimenter: Mr Zied Solomon

DOI: 10.5286/ISIS.E.RB1520495

ISIS Experiment Number: RB1520495

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Adrian Hillier et al; (2015): Using negative muons as a non-destructive probe of biomaterials, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1520495

Data is released under the CC-BY-4.0 license.