This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Investigating liposome sensitivity towards phospholipases for applications in diagnostics and drug delivery
Abstract: Liposomes are lipid-based, water-filled vesicles with wide-ranging applications in diagnostics and drug delivery. Phospholipases (PLs) are enzymes that cleave specific bonds in phospholipids. Reactions of PLs with liposomes are of huge interest on both an application led and basic research level. PLC and D are known markers for many diseases, but little is known about their effect on liposomes. We propose a series of kinetic experiments measuring five liposome formulations of interest as they are incubated with four PLs. The invaluable data provided on the effect of PLs on membrane bilayer thickness and permeability/fluidity, liposome stability and size distribution, answer an interesting basic research question and are vital to develop much-needed diagnostic and screening assays/drug delivery vectors for e.g. tuberculosis, cancers, Alzheimer's disease, atherosclerosis and depression.
Principal Investigator: Dr Margaret Holme
Experimenter: Dr Cecile Dreiss
Experimenter: Professor Molly Stevens
Experimenter: Dr Michael Thomas
Local Contact: Dr Richard Heenan
Experimenter: Dr Alex Brogan
DOI: 10.5286/ISIS.E.RB1510557
ISIS Experiment Number: RB1510557
Part DOI | Instrument | Public release date | Download Link |
---|---|---|---|
10.5286/ISIS.E.63530017 | SANS2D | 16 September 2018 | Download |
- | LARMOR | 16 September 2015 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Margaret Holme et al; (2015): Investigating liposome sensitivity towards phospholipases for applications in diagnostics and drug delivery, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1510557
Data is released under the CC-BY-4.0 license.