ISIS Neutron and Muon Source Data Journal

How does the anti-tumor drug paclitaxel change the dynamics on breast cancer cells?

Abstract: Cells are complex systems where small fragments play an interdependent role. The functionality of these systems can be distinct at different length and timescales, depending on physiological conditions or cells type. For example, cancer cells are more flexible than the healthy ones. Thus, understanding cancer cells flexibility is the first step to elucidate how and why they migrate and adhere to different tissues. Another point about the dynamics of cancer cells is the mechanism of action of the drug paclitaxel that bonds to the structural framework of cancer cells, the cytoskeleton, and inhibits their motions and division. Then, a cancer cell treated with paclitaxel should present changes on flexibility. Understanding such changes at distinct timescales might provide additional information on paclitaxel´s action and support the development of new and less toxic drugs.

Principal Investigator: Mr Murillo Longo Martins
Experimenter: Professor Heloisa Nunes Bordallo
Local Contact: Dr Svemir Rudic
Experimenter: Mr Jose Pereira

DOI: 10.5286/ISIS.E.RB1520341

ISIS Experiment Number: RB1520341

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Mr Murillo Longo Martins et al; (2015): How does the anti-tumor drug paclitaxel change the dynamics on breast cancer cells?, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1520341

Data is released under the CC-BY-4.0 license.