ISIS Neutron and Muon Source Data Journal

The use of magnetic contrast layers for neutron reflectivity to investigate non-lamellar lipid liquid crystalline nanoparticle interactions

Abstract: The search for new clever ways to deliver drugs, which often are not possible to dissolved in water, has lead to the development lipid based small particles. These particles can dissolve many different types of drugs that so far has been hard to solubilize. They can be used on the skin, eaten and be injected. Although they are based on natural lipids they have an intriguing internal structure which explains the capability to solubilize the drugs. They are also sticky and can be design so that the interacts with cells, more specifically with the cell-membrane that keeps the cell intact. The cell membrane also consists of lipids, so we want to know how the particles interact with these membrane. We are here using models of membranes with different properties and we use neutrons to see what happens when the drug delivery particle meets the membranes.

Principal Investigator: Professor Tommy Nylander
Experimenter: Mr Christopher Hirst
Experimenter: Miss Jenny Andersson
Local Contact: Dr Nina-Juliane Steinke
Experimenter: Ms Maria Valldeperas Badell
Experimenter: Dr Aleksandra Dabkowska
Experimenter: Dr Gunnar Palsson
Experimenter: Dr Justas Barauskas

DOI: 10.5286/ISIS.E.RB1520394

ISIS Experiment Number: RB1520394

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Tommy Nylander et al; (2015): The use of magnetic contrast layers for neutron reflectivity to investigate non-lamellar lipid liquid crystalline nanoparticle interactions , STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1520394

Data is released under the CC-BY-4.0 license.