ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Effect of oxidation on lipid raft formation: a SANS study
Abstract: The separation of particular lipids in cell membranes into liquid ordered and liquid disorder regions is thought to have a major influence of the functioning of membrane proteins. In this proposal we will examine changes to the ordering of lipids following oxidation events. Small angle neutron scattering will be used in combination with contrast variation as a non-invasive method to detect changes to the size of the lipid rafts (microdomains) as lipid vesicles are oxidized in situ. The vesicles will be prepared from a ternary mixture of lipids known to form rafts at low temperatures but not high temperatures, DPPC:DOPC:chol in ratios of 2:2:1 and 1:1:1.
Principal Investigator: Dr Katherine Thompson
Experimenter: Professor Jayne Lawrence
Experimenter: Dr Ivana Knyght
Experimenter: Dr Ann Terry
DOI: 10.5286/ISIS.E.RB1510342
ISIS Experiment Number: RB1510342
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.61784977 | SANS2D | 23 June 2018 | Download |
| 10.5286/ISIS.E.61003068 | SANS2D | 23 June 2018 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
Select the data format above to find
out more about it.
Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Katherine Thompson et al; (2015): Effect of oxidation on lipid raft formation: a SANS study, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1510342
Data is released under the CC-BY-4.0 license.
