ISIS Neutron and Muon Source Data Journal

Folated derivatized nanoemulsions for the treatment of cancer

Abstract: Nanoemulsions (NE) i.e. nanoparticles containing a fluid lipid or oil dispersed in water and stabilized by a surfactant particles have attracted considerable attention as vehicles for the delivery of poorly-water soluble drugs. We have recently developed a series of novel nanoemulsions containing soybean oil as the disperse phase and stabilised by the non-ionic surfactant, oleyl polyoxethylene (10) ether. Significantly a proportion of the surfactant molecules contain a folic acid receptor targeting group on the terminal hydroxyl to enable cellular targeting of the nanoemulsions. The proposed SANS study will determine the effect of the presence of the targeting moiety on the properties of the nanoparticles. The insight provided by the study should provide a better understanding of the potential of NE as vehicles for drug delivery.

Principal Investigator: Professor Jayne Lawrence
Experimenter: Ms Orathai Loruthai
Experimenter: Ms Yuvared Luangwitchajaroen

DOI: 10.5286/ISIS.E.RB1510573

ISIS Experiment Number: RB1510573

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jayne Lawrence et al; (2015): Folated derivatized nanoemulsions for the treatment of cancer, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1510573

Data is released under the CC-BY-4.0 license.