ISIS Neutron and Muon Source Data Journal

A Total Scattering Study of Aqueous Dopamine Under Conditions of Increased Hydrophobicity and Salinity

Abstract: We request 3 days on SANDALS to study the interactions of the neurotransmitter dopamine hydrochloride in a 1:19 methanol:water mixture and also in an aqueous 3M NaCl solution. This work builds on our previous study of dopamine hydrochloride in aqueous solution in which the conformation of dopamine in solution was assessed together with the hydration of the molecule. The methanol:water solution and aqueous NaCl solution both provide a more complex environment in which to study the conformation and interactions of the dopamine molecule thus simulating aspects of the in vivo environment. The results will enable further assessment of why dopamine does not cross the blood-brain barrier, while its structurally similar precursor, L-dihydroxyphenylalanine, does.

Principal Investigator: Dr Sam Callear [Deactivated]
Experimenter: Dr Sylvia McLain
Experimenter: Dr Silvia Imberti
Experimenter: Mr Andrew Johnston

DOI: 10.5286/ISIS.E.RB1510037

ISIS Experiment Number: RB1510037

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Sam Callear [Deactivated] et al; (2015): A Total Scattering Study of Aqueous Dopamine Under Conditions of Increased Hydrophobicity and Salinity, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1510037

Data is released under the CC-BY-4.0 license.