ISIS Neutron and Muon Source Data Journal

Interaction of sugars and a model peptide

Abstract: We propose to perform a NDIS experiments at the SANDALS diffractometer at T = 300 K on 7 aqueous solutions of NMA and trehalose and NMA and glucose, aimed at investigating the interaction of the two sugars with N-methylacetamide in solution. We have previous evidence of strong differences in the hydration properties of the two sugars, which may have a counterpart in the interaction of sugars with NMA, where NMA is a model system for the amide linkage of peptides and proteins. Investigating the interaction of this small molecule with trehalose and glucose in aqueous solution may address the longstanding question about the highest effectiveness of trehalose as a bio-protectant, compared to glucose. Indeed it is not yet clear if trehalose exploits its action by substituting water in the protein hydration shell, or not.

Principal Investigator: Professor Maria Antonietta Ricci
Experimenter: Dr Laura Maugeri
Experimenter: Dr Sylvia McLain
Experimenter: Professor Fabio Bruni

DOI: 10.5286/ISIS.E.RB1510043

ISIS Experiment Number: RB1510043

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Maria Antonietta Ricci et al; (2015): Interaction of sugars and a model peptide, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1510043

Data is released under the CC-BY-4.0 license.