ISIS Neutron and Muon Source Data Journal

DRUG EFFECTS ON INTRACELLULAR WATER DYNAMICS: CISPLATIN IN HUMAN CANCER CELLS

Abstract: Water dynamics plays a vital role in biochemical processes in a living organism. Intracellular water structure and dynamics are known to be changed by the presence of biomolecules or extrinsic entities (e.g. drugs), while in turn water is prone to disturb the conformation and function of biomolecules. Disruption of the coherent structure of cellular water by even very subtle stimuli is expected to have a significant cost at the functional level and may even induce pathology.The present study aims at extending this concept to the activity of pharmacological agents. Upon a successful exploratory experiment (OSIRIS/RB1400034), the QENS technique will be used to probe the effect of an anticancer drug (cisplatin) on water dynamics in human cancer cells. This is an innovative way of tackling the drug´s pharmacodynamics leading to an improved understanding of its in vivo mode of action.

Principal Investigator: Dr Maria Paula Marques
Experimenter: Dr Victoria Garcia Sakai
Experimenter: Mrs Louise Hatter
Experimenter: Dr Ana Batista de Carvalho
Experimenter: Professor Luis Alberto Batista de Carvalho

DOI: 10.5286/ISIS.E.RB1510054

ISIS Experiment Number: RB1510054

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Maria Paula Marques et al; (2015): DRUG EFFECTS ON INTRACELLULAR WATER DYNAMICS: CISPLATIN IN HUMAN CANCER CELLS, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1510054