ISIS Neutron and Muon Source Data Journal

Membrane-stacking properties of myelin proteins

Abstract: Myelin is the multilamellar structure that ensheaths axons and accelerates nervous impulses in the nervous system. The fine structure of myelin remains to be further characterized on the biomolecular scale. There are many myelin proteins that contribute to myelin membrane stacking and are involved in demyelinating diseases. We propose an experiment at the INTER neutron reflectometer, where the properties of these proteins can be investigated on supported stacked lipid bilayers. The proteins and their properties have already been characterized using other methods, but the use of neutrons allow us to probe for biomolecular distances in biomimetic systems. This helps us understand the ultrastructure of myelin from a structural aspect. In this proposal we ask for 4 days of beamtime to carry out measurements involving three abundant myelin proteins in various lipid environments and contrasts.

Principal Investigator: Dr Petri Kursula
Experimenter: Miss Saara Laulumaa
Experimenter: Dr Arne Raasakka

DOI: 10.5286/ISIS.E.RB1510294

ISIS Experiment Number: RB1510294

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Petri Kursula et al; (2015): Membrane-stacking properties of myelin proteins, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1510294

Data is released under the CC-BY-4.0 license.