ISIS Neutron and Muon Source Data Journal

DRUG EFFECTS ON INTRACELLULAR WATER: CISPLATIN IN HUMAN CANCER CELLS

Abstract: Within a biological system such as a cell or tissue, water structure and dynamics are known to be changed by the presence of biomolecules or extrinsic entities (e.g. drugs), while in turn water is prone to disturb the conformational behaviour and function of biomolecules. Disruption of the coherent structure of cellular water by even very subtle stimuli is expected to have a significant cost at the functional level, and may even induce pathology.The present study aims at extending this concept to the activity of pharmacological agents. The INS technique will be used to probe the effect of an anticancer drug (cisplatin) on intracellular water structure in human cancer cells.This is an innovative way of tackling the drug´s pharmacodynamics leading to an improved understanding of its in vivo mode of action.

Principal Investigator: Dr Luis Alberto Batista de Carvalho
Experimenter: Dr Pedro Duarte Vaz
Experimenter: Dr Maria Paula Marques
Experimenter: Dr Ana Batista de Carvalho
Experimenter: Dr Victoria Garcia Sakai
Experimenter: Mrs Louise Hatter

DOI: 10.5286/ISIS.E.RB1510053

ISIS Experiment Number: RB1510053

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Luis Alberto Batista de Carvalho et al; (2015): DRUG EFFECTS ON INTRACELLULAR WATER: CISPLATIN IN HUMAN CANCER CELLS, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1510053