ISIS Neutron and Muon Source Data Journal

Micellar aggregates of direct and reverse Tetronics for enhanced drug solubilisation

Abstract: Amphiphilic linear surfactants based on PEO and PPO triblock copolymers, known as Pluronics, exhibit a rich polymorphism and have been extensively studied for their applications in drug delivery and targeting. This work focuses on a promising and yet far less studied family of polymeric surfactants based on PEO and PPO known as Tetronics, which are four-armed (X-shaped) copolymers. Tetronics show a clear advantage over Pluronics because of their pH-responsiveness. In this proposal, we seek to establish the detailed structure of Tetronic micelles and in particular the mixtures of direct and reverse Tetronics which have been show to significantly enhance drug solubilisation, as a function of pH and temperature. This fundamental structural understanding is essential for the subsequent development of drug-carriers of Tetronic micelles with tailored release properties.

Principal Investigator: Dr Cecile Dreiss
Experimenter: Professor Gustavo Gonzalez-Gaitano
Experimenter: Dr Jose Ramon Isasi

DOI: 10.5286/ISIS.E.RB1510551

ISIS Experiment Number: RB1510551

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Cecile Dreiss et al; (2015): Micellar aggregates of direct and reverse Tetronics for enhanced drug solubilisation, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1510551

Data is released under the CC-BY-4.0 license.