ISIS Neutron and Muon Source Data Journal

A SANS study of nano-gels with a temperature tunable bio-interface

Abstract: Hyaluronic acid (HA) plays a key role in tumour cell bio-adhesion and, as such, this interaction opens up possibilities for targeted tumour pathologies We have created a cross-linked hydrogel micro-particle targeting system based on HA-PNiPAAm. PNiPAAm induces a volume phase transition (VPT) at 36C above which the micro-particle ¿shrinks¿ and a core-shell structure emerges (hydrophilic HA covering hydrophobic PNiPAAm) Below 36C the chains mix randomly Micro-particle surface morphology is vital for effective cell adhesion yet little is know about how the surface structure of our system evolves as the VPT is crossed Such information would allow us to understand what the tumour cell ¿feels¿ on the particle surface To answer this question wish to perform SANS experiments (20, 40oC) using two gel types: one chemically and one physically cross-linked but both with a similar thermo-responsivity

Principal Investigator: Professor Gaio Paradossi
Experimenter: Dr Mark Telling
Experimenter: Dr Barbara Cerroni
Experimenter: Dr Fabio Domenici

DOI: 10.5286/ISIS.E.RB1510287

ISIS Experiment Number: RB1510287

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Gaio Paradossi et al; (2015): A SANS study of nano-gels with a temperature tunable bio-interface, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1510287

Data is released under the CC-BY-4.0 license.