ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
SOLVENT-MATCHING SANS ON COMPLEXES FORMED BETWEEN DNA AND SHORT AMPHIPHILIC PEPTIDES
Abstract: We will perform SANS investigations on complexes formed between peptide amphiphiles (PAs) and the plasmid DNA pEGFP-N1. Previous SAXS data have shown that our PAs form nanoscopic fibrils or layered structures, thus potentially able to host DNA. We propose solvent matching experiments where D2O/H2O ratio will be varied to separately match the contrast of PAs and DNA. Our data will be combined with cell assays following transfection with the peptide/plasmid complexes to determine a relationship between structure and delivery.
Principal Investigator: Professor Ian Hamley
Experimenter: Mr Steven Kirkham
Experimenter: Dr Emerson SILVA
Local Contact: Dr Steve King
DOI: 10.5286/ISIS.E.RB1510029
ISIS Experiment Number: RB1510029
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.58451608 | LOQ | 26 March 2018 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Professor Ian Hamley et al; (2015): SOLVENT-MATCHING SANS ON COMPLEXES FORMED BETWEEN DNA AND SHORT AMPHIPHILIC PEPTIDES, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1510029
Data is released under the CC-BY-4.0 license.
