ISIS Neutron and Muon Source Data Journal

Intercalation of Ciprofloxacin into Lithium - Fluorohectorite at acid and basic pH.

Abstract: Using quasielastic neutron scattering (QENS) we will investigate the intercalation of Ciprofloxacin (CIPRO) into the synthetic clay Lithium – Fluorohectorite (LiFh) to understand how the pH of the solution during the drug intercalation influences the process. X-ray experiments performed at room indicated that the drug intercalation is strongly related to the pH. In addition, preliminary inelastic neutron scattering results are indicating that the drug intercalation process is changing the water/clay interactions. Using the backscattering spectrometer IRIS we aim to verify how the local dynamics as well as the local environment of the drug molecule is modified when varying the preparation conditions. To achieve our goal we propose to measure the quasielastic spectra at 100 K, 200 K and room temperature of CIPRO, pure LiFh and CIPRO intercalated into LiFh, prepared at acid and basic pH.

Principal Investigator: Professor Heloisa Nunes Bordallo
Experimenter: Professor Marcella Berg
Experimenter: Mr Éverton Carvalho dos Santos
Local Contact: Dr Ian Silverwood
Experimenter: Dr Felix Jimenez-Villacorta

DOI: 10.5286/ISIS.E.RB1620291

ISIS Experiment Number: RB1620291

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Heloisa Nunes Bordallo et al; (2016): Intercalation of Ciprofloxacin into Lithium - Fluorohectorite at acid and basic pH., STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1620291

Data is released under the CC-BY-4.0 license.