ISIS Neutron and Muon Source Data Journal

Interaction of a pH-sensitive Polymer with a Model Lipid Membrane in the Form of Unilamellar Vesicles as Studied by SANS

Abstract: This SANS experiment was proposed by 4 PhD students from 3 different institutions in a Marie-Curie Training Network. They are all in the second year of their PhD and their individual research has come to the common point where they all wish to understand how a membrane lytic copolymer interacts with lipid membrane bilayer. As they all have acquired extensive skills in unilamellar vesicles they request 3 days of SANS2d beam time to examine how the copolymer interacts with the vesicular membranes under different pH conditions. As this is the first time SANS is used for structural studies, it is useful to explore the concentration of the vesicles and polymer suitable for the SANS measurements at the start. This work will provide valuable molecular insight of modes of actions of the copolymers to different membranes

Principal Investigator: Professor Jian Lu
Local Contact: Dr Steve King
Local Contact: Dr James Doutch
Experimenter: Dr Arwel Hughes
Experimenter: Dr Luke Clifton
Experimenter: Dr John Webster
Experimenter: Dr Zongyi Li
Experimenter: Miss Daniela Ciumac
Experimenter: Mr Charles Smith
Experimenter: Dr Xuzhi Hu
Experimenter: Miss Monika Kluzek
Experimenter: Professor Jiqian Wang
Experimenter: Professor Hai Xu

DOI: 10.5286/ISIS.E.RB1620303

ISIS Experiment Number: RB1620303

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jian Lu et al; (2016): Interaction of a pH-sensitive Polymer with a Model Lipid Membrane in the Form of Unilamellar Vesicles as Studied by SANS , STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1620303

Data is released under the CC-BY-4.0 license.