ISIS Neutron and Muon Source Data Journal

Perfluorocarbon-loaded polymeric nanoparticles with multiple perfluorocarbon domains for clinical and in vivo imaging

Abstract: Ultrasound is a very attractive and patient-friendly imaging technique, as it is easy to use, fast and non-invasive. Nevertheless, its use is severely limited by the low stability of current contrast agents, as they contain gaseous or vaporizing phase. We developed perfluorocarbon-loaded poly(lactide-co-glycolide) nanoparticles (NPs), which are suitable for long-term imaging, in a time-scale of days. However, the mechanism of contrast generation is completely unclear. The internal structure of our NPs appears completely different from currently reported perfluorocarbon-loaded colloids. Thus, elucidating the internal structure of these nanoparticles is a key to describe the mechanism of acoustic contrast generation. As SANS has been successfully applied by other researchers to study fluorinated colloids, we propose SANS to investigate the structure of our NPs.

Principal Investigator: Dr Olga Koshkina
Local Contact: Dr Sarah Rogers
Experimenter: Dr Francesca Baldelli Bombelli
Experimenter: Miss Edyta Swider

DOI: 10.5286/ISIS.E.RB1620402

ISIS Experiment Number: RB1620402

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Olga Koshkina et al; (2016): Perfluorocarbon-loaded polymeric nanoparticles with multiple perfluorocarbon domains for clinical and in vivo imaging, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1620402

Data is released under the CC-BY-4.0 license.