ISIS Neutron and Muon Source Data Journal

Effect of structure on the location of hydrophobic drugs in ionic surfactant monolayers

Abstract: Many drugs are both poorly water-soluble (hydrophobic) and lipophilic in nature and are therefore incorporated into surfactant micelles and monolayers. As the incorporation of drug into surfactant monolayers mirrors its distribution in surfactant micelles, the study of drug distribution into surfactant monolayers should provide useful information about the nature and extent of drug solubilisation. The present study aims to determine the amount incorporated and the extent of penetration of the hydrophobic drug testosterone enanthate into monolayers of dodecyltrimethylammonium bromide as well as the hydrophobic drugs, adrenosterone and 4-cholesten-3-one in monolayers formed by the surfactant, sodium dodecyl sulphate at the air/water surface. The study will provide invaluable information in understanding the location of the drugs in the surfactant micelles.

Principal Investigator: Professor Jayne Lawrence
Local Contact: Dr Maxmilian Skoda
Experimenter: Miss yanan shao
Experimenter: Ms Orathai Loruthai
Experimenter: Dr Hisham Al-Obaidi

DOI: 10.5286/ISIS.E.RB1610441

ISIS Experiment Number: RB1610441

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jayne Lawrence et al; (2016): Effect of structure on the location of hydrophobic drugs in ionic surfactant monolayers, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1610441

Data is released under the CC-BY-4.0 license.