ISIS Neutron and Muon Source Data Journal

Comparative Interaction Studies of Antimicrobial Agents on Floating Asymmetric Bacterial Membrane Models

Abstract: The outer membrane (OM) of Gram-Negative bacteria (GNB) is an asymmetric structure which contains complex lipids known as lipopolysaccharides (LPSs) on the outer surface. LPSs comprise the membrane anchoring Lipid-A, the anionic core oligosaccharides and the very large, solution facing O-antigen which acts as a hydrophilic barrier to antibiotics. We have recently achieved an accurate model of the outer membrane using short chain LPS and now wish to start examining its interaction with antimicrobial peptides and proteins. These will include the antibiotic polymyxin, human innate immune peptide cathelicidin, LPS specific bacteriocin, colicin N and a beta defensin.

Principal Investigator: Professor Jeremy Lakey [Deactivated] [Deactivated]
Experimenter: Dr Anton Le Brun
Experimenter: Dr Luke Clifton
Local Contact: Dr Christy Kinane
Experimenter: Dr Stephen Holt
Experimenter: Dr Nicolò Paracini

DOI: 10.5286/ISIS.E.RB1610417

ISIS Experiment Number: RB1610417

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jeremy Lakey [Deactivated] [Deactivated] et al; (2016): Comparative Interaction Studies of Antimicrobial Agents on Floating Asymmetric Bacterial Membrane Models , STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1610417

Data is released under the CC-BY-4.0 license.