ISIS Neutron and Muon Source Data Journal

Interaction of Xe with Membranes Using µSR

Abstract: The mechanism of action of inhalation anaesthetics such as N2O and the inert gases are unclear. Direct binding to receptor sites on membranes would rely on weak intermolecular interactions. A plausible alternative is an indirect effect though changes in the dynamics of the lipids forming the membranes in which the receptors are anchored. Previous experiments have established that the chain dynamics in DOPC are altered subtly upon exposure to N2O. Xe is a more potent anaesthetic than N2O, indeed a safe breathing mixture will give general anaesthesia. Consequently this proposal seeks to determine whether a DOPC bilayers exposed to Xe shows a more pronounced effect on the dynamics of the lipids. Furthermore, methyl oleate will be used as a model to give the anisotropic hyperfine coupling constant required to simulate the previously collected ALC-mSR spectra.

Principal Investigator: Dr Nigel Clayden
Experimenter: Dr Stephen Cottrell

DOI: 10.5286/ISIS.E.RB1610373

ISIS Experiment Number: RB1610373

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Nigel Clayden et al; (2016): Interaction of Xe with Membranes Using µSR, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1610373

Data is released under the CC-BY-4.0 license.