ISIS Neutron and Muon Source Data Journal

Effect of polar solvent on the formation of reverse phospholipid microemulsions

Abstract: It is the aim of the proposal is to perform small angle neutron scattering (SANS) studies combined with contrast variation to determine the size and structure of the phospholipid-stabilised microemulsions prepared using a non-polar solvent (namely a diol) and a pharmaceutically acceptable oil (here ethyl oleate). Of particular interest is the effect of the structure of the non-aqueous solvent on microemulsion formation. Due to refractive index matching it is not possible to perform these studies using light scattering. Consequently neutron studies are essential to determine the formation of microemulsions these water-free systems. The studies will inform the future development of these interesting and potential important delivery systems.

Principal Investigator: Professor Jayne Lawrence
Experimenter: Dr Ann Terry
Experimenter: Ms Orathai Loruthai
Experimenter: Miss yanan shao
Experimenter: Miss Simona-Vyara Kolarova
Local Contact: Dr Sarah Rogers
Experimenter: Professor Gino Martini
Experimenter: Dr Dave Barlow

DOI: 10.5286/ISIS.E.RB1610465

ISIS Experiment Number: RB1610465

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jayne Lawrence et al; (2016): Effect of polar solvent on the formation of reverse phospholipid microemulsions, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1610465

Data is released under the CC-BY-4.0 license.