ISIS Neutron and Muon Source Data Journal

A neutron study of capability of aggregation of the Abeta1-40, Abeta1-42 and AbetapE3-42 peptides.

Abstract: The aim of the proposed SANS experiment is to study the capability of aggregation, the shape and the size of aggregates of three amyloid peptides named (Abeta1-40, Abeta1-42 and AbetapE3-42). These peptides are involved in neurodegenerative pathologies, such as Alzheimer’s disease, Parkinson with dementia, etc. Beta-amyloid peptide chains under study are suspected to contribute to the disease processes because these molecules can aggregate to form soluble oligomers and insoluble fibrils, leading to tissue damage. We have performed SANS Xpress measurements on SANS2D with good preliminary results: the presence of AbetapE3-42 neo-formation aggregates, and the absence of aggregates for the Abeta1-40 and Abeta1-42.

Principal Investigator: Dr Giulia Festa
Experimenter: Dr Steve King
Experimenter: Dr Victoria Garcia Sakai
Experimenter: Miss Laura Arcidiacono
Experimenter: Dr giulia M Sancesario
Experimenter: Professor Carla Andreani
Experimenter: Professor Roberto Senesi
Experimenter: Professor Giuseppe Sancesario

DOI: 10.5286/ISIS.E.RB1610097

ISIS Experiment Number: RB1610097

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Giulia Festa et al; (2016): A neutron study of capability of aggregation of the Abeta1-40, Abeta1-42 and AbetapE3-42 peptides., STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1610097

Data is released under the CC-BY-4.0 license.