ISIS Neutron and Muon Source Data Journal

Effect of serum and electrolyte on the structure of nanoemulsions intended for the treatment of cancer

Abstract: Nanoemulsions (NE) i.e. nanoparticles containing a fluid lipid or oil dispersed in water and stabilized by a surfactant particles have attracted considerable attention as vehicles for the delivery of poorly-water soluble drugs. We have recently developed a series of novel nanoemulsions containing either trilaurin or soybean oil as the disperse phase and stabilised by the non-ionic surfactant, oleyl polyoxethylene (10) ether. In order to use the NE as vehicles for the delivery of cancer it is essential to understand the effect of electrolyte and plasma proteins on the structure of the NE. The proposed SANS study will therefore determine the effect of electrolyte and plasma proteins on the properties of the NE. The insight provided by the study should provide a better understanding of the potential of NE as vehicles for drug delivery.

Principal Investigator: Professor Jayne Lawrence
Experimenter: Ms Orathai Loruthai
Experimenter: Miss Simona-Vyara Kolarova
Local Contact: Dr Sarah Rogers
Experimenter: Miss yanan shao
Experimenter: Dr Dave Barlow
Experimenter: Dr Ann Terry

DOI: 10.5286/ISIS.E.RB1610453

ISIS Experiment Number: RB1610453

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jayne Lawrence et al; (2016): Effect of serum and electrolyte on the structure of nanoemulsions intended for the treatment of cancer, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1610453

Data is released under the CC-BY-4.0 license.