ISIS Neutron and Muon Source Data Journal

Investigation of the structure and formation of alphasynuclein-lipid co-aggregates

Abstract: Alpha-synuclein is tan intrinsically disordered protein whose aggregates are an hallmark of Parkinson's Disease (PD). Alpha-syn is known to associate with lipid membranes and their interaction and aggregation is believed to be important for the PD pathology. Indeed, the process of amyloid formation has been associated with cell injury through mechanisms that are not understood.The overall goal of this project is a detailed understanding of the amyloid aggregation in the presence of lipid membranes, and molecular level characterization of amyloid-lipid co-aggregates. The use of isotope labels will enable us to detect structural information of the protein-lipids interactions. Focus will be on the amyloid protein alpha-syn together with model lipid membranes with different compositions in order to understand the role of the lipid composition and underlying the driving forces.

Principal Investigator: Dr Ilaria Idini
Experimenter: Mr Ricardo Gaspar
Local Contact: Dr James Doutch
Experimenter: Ms Anne Martel
Experimenter: Professor Sara Linse
Experimenter: Dr Andrew Jackson
Experimenter: Professor Emma Sparr

DOI: 10.5286/ISIS.E.RB1610294

ISIS Experiment Number: RB1610294

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Ilaria Idini et al; (2016): Investigation of the structure and formation of alphasynuclein-lipid co-aggregates , STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1610294

Data is released under the CC-BY-4.0 license.