ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Adsorption of Monoclonal Antibodies at the Solid/liquid Interface
Abstract: We propose to use neutron reflection to study the interfacial adsorption of 2 novel bispecific therapeutic antibodies at the silicon oxide/water interface. To enpower each of these antibodies with 2 functional targets, the antibodies have been bioengineered with additional domains and as a result, their structural stability may alter. Current ellipsometric studies have revealed different dynamic adsorption and greater adsorbed amounts at equilibration. The aim of the neutron study is to reveal structural details against concentration, pH and ionic strength and how these factors affect their extent of desorption.
Principal Investigator: Professor Jian Lu
Experimenter: Dr Zongyi Li
Experimenter: Mr Ruiheng Li
Experimenter: Dr Lisa Pan
Experimenter: Mr Robert Holman
Experimenter: Dr John Webster
Local Contact: Dr Mario Campana
Experimenter: Dr Chris van der Walle
DOI: 10.5286/ISIS.E.RB1610266
ISIS Experiment Number: RB1610266
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.79108844 | SURF | 25 April 2019 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
Select the data format above to find
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Professor Jian Lu et al; (2016): Adsorption of Monoclonal Antibodies at the Solid/liquid Interface, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1610266
Data is released under the CC-BY-4.0 license.
