ISIS Neutron and Muon Source Data Journal

Chain exchange mechanism of complex coacervate core micelles

Abstract: Complex coacervates have been studied for a long time for their medical applications and unusual physical-chemical properties: they are dense networks of poly-electrolytes, that dissolve instead of flocculating when exposed to high salt concentrations. Despite being dense, they are fully permeable to water, yet they are capable of strongly binding heavy metal ions or large (bio-)molecules, making them useful as drug carriers. By modifying them to form micelles, the micelle cores become small coacervate networks; Complex Coacervate Core Micelles (C3Ms). Unlike gels, they are dispersed into solution easily and have an enormous active surface area. The form and structure of C3Ms are quite well known, but the exchange mechanism of polymers between micelles is unknown. By performing contrast decay time-resolved SANS, we will determine if polymers migrate separately or in charge-neutral pairs.

Principal Investigator: Dr Wim Bouwman
Experimenter: Mr Jurrian Bakker
Experimenter: Dr Clément Guibert
Experimenter: Dr Ad van Well
Local Contact: Dr Sarah Rogers
Experimenter: Dr Ilja Voets

DOI: 10.5286/ISIS.E.RB1520120

ISIS Experiment Number: RB1520120

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Wim Bouwman et al; (2015): Chain exchange mechanism of complex coacervate core micelles, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1520120

Data is released under the CC-BY-4.0 license.