ISIS Neutron and Muon Source Data Journal

Structural Studies of Mixed Monolayers of Sulfobetaines with Phospholipids

Abstract: Sulfobetaines are zwitterionic surfactants where the headgroup charges are arranged in the opposite manner to those found in phosphotidylcholine lipid headgroups. Sulfobetaines are relatively non-toxic and are being considered for drug delivery and biomaterials applications. We therefore wish to study the interactions between model lipid membranes of DMPC with insoluble sulfobetaines. We have measured X-ray reflectivity from these systems but require neutron reflectivity data with contrast variation to be able to gain information on the details of headgroup interactions in these systems. We have synthesised novel double-tail sulfobetaine surfactants, and their corresponding single tail versions in our lab, so have both deuterated and hydrogenated surfactants available. These NR measurements will enable publication of this work, and form an initial study in ongoing work.

Principal Investigator: Professor Karen Edler
Experimenter: Dr Stephen Hall
Experimenter: Miss Andi Di
Experimenter: Ms Cecilia Tognoloni
Experimenter: Dr Andrew McCluskey
Experimenter: Dr Oliver Hammond
Experimenter: Miss Naomi Elstone
Local Contact: Dr Maxmilian Skoda
Experimenter: Dr Thomas Arnold
Experimenter: Dr Naomi Elstone

DOI: 10.5286/ISIS.E.RB1610351

ISIS Experiment Number: RB1610351

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Karen Edler et al; (2016): Structural Studies of Mixed Monolayers of Sulfobetaines with Phospholipids, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1610351

Data is released under the CC-BY-4.0 license.