ISIS Neutron and Muon Source Data Journal

Location of the lipophilic drug testosterone propionate at the oil-water interface

Abstract: Solubilisation of poorly-water soluble drug in surfactant micelles is an attractive means of increasing the apparent aqueous solubility of such drugs in order to administer the drug. Surprisingly little is known, however, about the relationship between surfactant and drug structure and the ability of the micelle to solubilise drug. As a drug’s distribution in a surfactant monolayer is related to its distribution in the corresponding micelles, the present study aims to investigate the location of testosterone propionate (TP) in an SDS monolayer at the oil-water interface using neutron reflectometry in combination with contrast variation. The data thus obtained will be compared with the corresponding data we recently obtained at the simpler air-water interface. The study will provide invaluable information of the location of TP in SDS micelles.

Principal Investigator: Professor Jayne Lawrence
Experimenter: Miss yanan shao
Experimenter: Dr Katarzyna Zielinska
Experimenter: Dr Ali Zarbakhsh
Experimenter: Dr John Webster

DOI: 10.5286/ISIS.E.RB1610457

ISIS Experiment Number: RB1610457

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jayne Lawrence et al; (2016): Location of the lipophilic drug testosterone propionate at the oil-water interface , STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1610457

Data is released under the CC-BY-4.0 license.